Yearly Archives: 2021

Kidney Pathophysiology Reseach Group

CnAα Inhibition Drives NFκB Activation Thereby Promoting Nox2-Mediated Oxidative Stress

  • April 27, 2021
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Aswathy M. Cheriyan, Adaku C. Ume, Cynthia E. Francis, Keyona N. King, Valerie A. Linck, Yun Bai, Hui Cai, Robert S. Hoover, Heping P. Ma, Jennifer L. Gooch, and Clintoria R. Williams Calcineurin inhibitors (CNIs) are vital immunosuppressive therapies in the management of inflammatory conditions. A long-term consequence is nephrotoxicity. In the kidneys, the primary, […]

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Kidney Pathophysiology Research Group

Calcineurin Inhibitors: a Double-Edged Sword

  • March 9, 2021
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Adaku C. Ume, Tara-Yesomi Wenegieme, and Clintoria R. Williams Recently, research has directed its interests into identifying molecular pathways implicated in calcineurin inhibitor (CNI)-induced renal fibrosis. An emerging body of studies investigating calcineurin (CnA) activity has identified distinct actions of two main ubiquitously expressed isoforms: CnAα and CnAβ. CNIs have the capacity to inhibit both […]

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