Yearly Archives: 2023

Kidney Pathophysiology Research Group

Tacrolimus Treatment Causes Kidney Damage

  • April 10, 2023
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Use of immunosuppressant calcineurin inhibitors (CNIs) is limited by irreversible kidney damage, hallmarked by renal fibrosis. CNIs directly damage many renal cell types. Given the diverse renal cell populations, additional targeted cell types and signaling mechanisms warrant further investigation. We hypothesized that fibroblasts contribute to CNI-induced renal fibrosis and propagate profibrotic effects via the transforming […]

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Kidney Pathophysiology Research Group

Zinc Supplementation: A Possible Offramp from the Road to End Stage Kidney Failure

  • March 1, 2023
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Ume, Adaku C.; Wenegieme, Tara-Yesomi; Adesina, Sherry E.; Williams, Clintoria R. Globally, over 103 million individuals are afflicted by CKD, a silent killer claiming the lives of 1.2 million people annually. CKD is characterized by five progressive stages, in which dialysis and kidney transplant are life-saving routes for patients with end stage kidney failure. While kidney damage impairs kidney function […]

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