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Kidney Pathophysiology Research Group

Tacrolimus Treatment Causes Kidney Damage

  • April 10, 2023
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Use of immunosuppressant calcineurin inhibitors (CNIs) is limited by irreversible kidney damage, hallmarked by renal fibrosis. CNIs directly damage many renal cell types. Given the diverse renal cell populations, additional targeted cell types and signaling mechanisms warrant further investigation. We hypothesized that fibroblasts contribute to CNI-induced renal fibrosis and propagate profibrotic effects via the transforming […]

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Kidney Pathophysiology Reseach Group

CnAα Inhibition Drives NFκB Activation Thereby Promoting Nox2-Mediated Oxidative Stress

  • April 27, 2021
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Aswathy M. Cheriyan, Adaku C. Ume, Cynthia E. Francis, Keyona N. King, Valerie A. Linck, Yun Bai, Hui Cai, Robert S. Hoover, Heping P. Ma, Jennifer L. Gooch, and Clintoria R. Williams Calcineurin inhibitors (CNIs) are vital immunosuppressive therapies in the management of inflammatory conditions. A long-term consequence is nephrotoxicity. In the kidneys, the primary, […]

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Kidney Pathophysiology Research Group

Calcineurin Inhibitors: a Double-Edged Sword

  • March 9, 2021
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Adaku C. Ume, Tara-Yesomi Wenegieme, and Clintoria R. Williams Recently, research has directed its interests into identifying molecular pathways implicated in calcineurin inhibitor (CNI)-induced renal fibrosis. An emerging body of studies investigating calcineurin (CnA) activity has identified distinct actions of two main ubiquitously expressed isoforms: CnAα and CnAβ. CNIs have the capacity to inhibit both […]

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