Daily Archives: March 9, 2021

Kidney Pathophysiology Research Group

Calcineurin Inhibitors: a Double-Edged Sword

  • March 9, 2021
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Adaku C. Ume, Tara-Yesomi Wenegieme, and Clintoria R. Williams Recently, research has directed its interests into identifying molecular pathways implicated in calcineurin inhibitor (CNI)-induced renal fibrosis. An emerging body of studies investigating calcineurin (CnA) activity has identified distinct actions of two main ubiquitously expressed isoforms: CnAα and CnAβ. CNIs have the capacity to inhibit both […]

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